治疗引起的周围神经损伤量表的信效度 及跨癌症类型的测量不变性检验

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Reliability validity and measurement invariance cross cancer types test of the Treatment-Induced Neuropathy Assessment Scale

AbstractObjective：Totestthereliabilityvalidityandross-groupmeasurementinvarianceoftheTreatment-InducedNeuropathy Assessment Scale.Methods：Conveniencesampling methodwasused toconductaquestionnaire surveyon392patients intheinpatient andoutpatientdepartmentsoftumor-relateddepartmentsof2tertiarygradeAhospitalsinTianjinandNanchangfromMarchtoJuly 2024.Results：The Chinese version of TNAS included 9 items and 2 subscales.The critical ratio t value of each item was 14.169-20.374 0 P<0.001 ）.The correlation coefficient r between the score of each item and the total score of the scale was 0.690-0.845（P<0.001） 1 Confirmatoryfactoranalysis（CFA）supportedthetwo-factormodel，andeachindicatorreachedtheidealfitingstandard.Thefactor loadingofeachitemofthescalewasO.6-0.90.TheCRofthetwosubscaleswereO.91and.912respectivelyTheAVEwere0.629 and0.778respectively.TheabsolutevalueoftecorrlationcoeficentbetweenthetwosubscalesasO.574.TheChineseversionof TNAS showed a positive correlation with EORTC QLQ-CIPN 20（r=0.460 P<0.001 ）.The Cronbach's α coefficient of the Chinese version of the TNAS was O.91O.The Cronbach's α coefficients of the two subscales were O.912 and O.915 respectively.The retest reliability was O.8O2.The Chinese version of the TNAS had measurement invariance acrossgroups in theequivalence test P>0.05）

Conclusions：TheCneseversionoftheTAShasgodreliabiltyalidityandmeasurementivarianceacrossgroupsndouldbe used to identify the severity of neuropathy in various cancer treatments.

Keywords cancer; treatment-induced peripheral neuropathy; scale;reliability; validity; measurement invariance

治疗引起的周围神经病变（uaueuuctuperipheralneuropathy，TIPN）是各种癌症治疗（手术、化疗及靶向疗法）所致的毒性症状，其症状包括疼痛、刺痛、麻木、对温度变化的敏感性增强以及精细运动技能受损等[1-2]。（剩余12539字）