微量营养素与2型糖尿病及其并发症关联性的孟德尔随机化研究

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AbstractObjectieToutildeliaadomatiotolateooudingfctorsandeseusalityaseaiettal causalrelationsipstweemronrientsadtye2diabeteselltusswellasisomplatsMethds：Leverainggeoeide asociation study（GWAS）data，theexposure factors encompassd15micronutrients including mineralssuchascopper，selenium， zinc，potassium，iron，magnesium，and calcium，as well as vitamins A， B6 ，folate， B12 ，C，D，E，and beta-carotene.The outcome variables weretype2diabeteselitusaditsomplcatisMendelianandomzationanalysisasconductedusingmetodssuchasinvsearance weighted（IVW），-Eggerndweightedmedanndsesitivityalyswereperfordesults：eresultsfroteiveaace weighted（IVW）methodand theweighted medianmethod indicatedthatatherosclerosis waspositivelycorelatedwithvitamin B12 levels andnegativelyoelatedwitviainAlevelsChonicealfureasnegativelyoelatedwithflaelevels.Type2dabeeslitus waspositivelycorelatedwithselenumlevelsanddiabeticmacularedemaaspositivelycorelatedwitionlevels.Theulivarate Mendelinrandomizationresutsrevealedthatseenumasanindependentifluencingfactorforype2diabetes，hilevitainAandviain B12 couldindependentlyaffecttheuenceofatheroslerosisConusis：Tisstudysugsts tatspecificmicroutrientsayplaya regulatoryroleintypediabetesanditscomplications.Thesefidingsprovidesupportindevelopingsientificandreasonabledietary guidelines and preventive strategies.

Keywordstype 2 diabetes melitus;complications; micronutrients; minerals;trace elements;Mendelian randomization摘要目的：通过孟德尔随机化方法去除混杂因素和反向因果偏倚，以确定微量营养素与2型糖尿病及其并发症的潜在因果关系。（剩余16653字）