PKM2及PARP14参与调控糖酵解的研究进展

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关键词：丙酮酸激酶M2型；聚腺苷二磷酸核糖聚合酶14；糖酵解；Warburg效应 中图分类号：R446.11文献标志码：A文章编号：1001-5779（2025）07-0689-05 DOI：10.3969/j. issn. 1001-5779.2025.07.014

Research progress on the regulation of glycolysis by PKM2 and PARP14

WU Zhi-peng1，LIU Jian-shuo²，DONG Jia-yi³，ZENG Ji-qiang²，LU Chen²，ZHU Ying2，4

（1.TheFirstClinicalMedicalSchoolofGannanMedicalUniversity；2.SchoolofMedicalTechnology，GannanMedical

University，Ganzhou，Jiangxi341oo；3.SchoolofLifeSciences，Nanchang University，Nanchang，Jiangxi330000；4. The First Affiliated Hospital of Gannan Medical University，Ganzhou，Jiangxi

Abstract：Glycolysis isoneofthe threemajorpathwaysofsugarmetabolismandakeylink incellularmetabolism.It plays acentralroleinenergyproductionand biosynthesis，andisalsocrucialfor maintainingcellularfunctions.Inthisprocess， thepyruvatekinase M2（PKM2）isozymeplaysapivotalroleasaregulatoryhubofthewarburg efect.Poly（ADP-ribose） polymerase 14（PARP14），as a multifunctional enzyme，is believed to affect the function of PKM2 through various mechanisms，thereby havingaprofound impacton glycolysisandthewarburg efect.This reviewdelves intothe multiple regulatory pathways of PARP14on the functionof PKM2，reveals the complex mechanisms ofPARP14 intheglycolytic process，provides a new perspective on the multifaceted roleof PARP14 in metabolic regulation，and on this basis ， proposespotentialnewtherapeuticstrategiesforvarious tumordiseases，layingacertain foundationforfutureresearchand clinical applications.

KeyWords：PyruvatekinaseM2；Poly（ADP-ribose）polymerase14；Glycolysis；Warburg effect

丙酮酸激酶（Pyruvatekinase，PK）在糖酵解途径中发挥重要作用，而其M2型（PyruvatekinaseM2，PKM2）异构体则是某些组织细胞糖酵解途径的关键限速因素[1]。（剩余13104字）