糖酵解及其产物在冠心病中的作用及机制
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关键词：糖酵解；丙酮酸；乳酸；三磷酸腺苷；烟酰胺腺嘌呤二核苷酸；冠状动脉粥样硬化性心脏病 中图分类号：R331文献标志码：A文章编号：1001-5779（2025）07-0621-09 DOI：10.3969/j.issn.1001-5779.2025.07.001
The role and mechanism of glycolysis and its products in coronary heart disease
ZHAO Li-wen1，LIU Jin1，GAO Xiu-rong'，LAI Yi-pan1，LIAO Zi-bing1，2，ZHONG Jia-ning1，2 （1.SchoolofBasic Medicine，Gannan Medical University；2.KeyLaboratoryof MinistryofEducation forCardiovascular and Cerebrovascular Diseases，Gannan Medical University，Ganzhou，Jiangxi ）
Abstract：Coronaryatherosclerotic heart diseaseisa cardiovascular disease that seriouslythreatenshuman health.Its pathogenesis involves multiple pathological processessuchaslipid metabolismdisorder，chronic inflammatoryresponse， oxidativestress，vascularendothelial dysfunctionand immuneregulation imbalance.Research has foundthatabnormal myocardial energy metabolism，especiallythe dysregulation ofthe glycolytic pathway，plays akeyrole intheocurrence and development of coronary heart disease.Glycolytic metabolic products such as lactic acid，pyruvic acid，adenosine triphosphate（ATP）and nicotinamide adenine dinucleotide（NADH） participate in the disease process byregulating anti-inflammatoryresponses，regulating lipid metabolism，maintaining vascularendothelialfunctionandinhibiting platelet agregation.These findings notonlyreveal theimportantroleof glycolysis inthepathogenesis ofcoronary heartdisease， but also providenew ideas forearly warningandtargetedtreatmentof the disease，making itahotresearcharea incurrent cardiovascularresearch.Thisarticlereviewsthemechanismoftheroleof glycolysisanditsmetabolicproducts in the occurrenceanddevelopmentofcoronaryheartdisease，andexplores itsclinical ransformationpotential，aiming toprovide theoreticalbasisandresearchdirectionsfortheoptimizationofcoronaryheartdiseasepreventionand treatmentstrategies.
Key words：Glycolysis；Pyruvate；Lactate；Adenosine triphosphate；Nicotinamide adenine dinucleotide；Coronary heartdisease
冠状动脉粥样硬化性心脏病（简称冠心病）是全球范围内致死和致残的主要疾病之一，其发病机制涉及脂质代谢异常、慢性炎症、氧化应激及血管功能障碍等多重因素[1。（剩余18071字）
