巨噬细胞代谢重编程调控慢加急性肝衰竭的机制与治疗前景

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基金项目：中央引导地方科技发展资金项目（科技创新基地建设）（236Z7749G）；河北省研究生创新资助项目（CXZZBS2026110）

Mechanism and treatment prospects of macrophage metabolic reprogramming in regulating acute-on-chronic liver failure

XIAO Ying，MA Luyuan，DONG Shilong，WANG Yadong，ZHAO Caiyan

DepartmentofInfectiousDiseases，HebeiMedical UniversityThirdHospital，ShijiazhuangO5oo51，China

Corresponding author： ZHAO Caiyan，zhaocy@hebmu.edu.cn （ORCID： 0000-000l-5997-4641）

Abstract：Metabolicreprogrammingisaprerequisiteandimportantmarkerformacrophagephenotypic transition，anddierent macrophage phenotypesare involvedinthepathogenesisofacute-on-chronic liverfailure（ACLF）byregulating thebalanceof inflammatoryresponses，therebybecomingthepotentialtargetsforACLFtreatment.Thisarticlefocusesonthechangesin macrophage metabolicreprogrammingduringACLFand itsmechanism in mediating ACLF severityandprognosis byregulating energymetabolismandimmuneinflammation，inorder toprovidenewideasanddirections fordeveloping preventionandcontrol strategies for ACLF based on macrophage metabolic reprogramming.

KeyWords：Acute-On-Chronic LiverFailure；Macrophages；Inflammation

Research funding：Central Guiding Local Technology Development Fund Project（Constructionof Scienceand Technology Innovation Base）（236Z7749G）； Hebei Province Graduate Innovation Funding Project （CXZZBS2026110）

慢加急性肝衰竭（acute-on-chronic liverfailure，ACLF）是指在慢性肝病基础上，短期内出现肝功能急性失代偿的临床综合征，短期病死率高达 20%～80%[1] 。（剩余11816字）