自身免疫性肝病基于肠道菌群的靶向治疗最新进展

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0009-0000-6803-247X）

Latestresearch advances in intestinal flora-based targeted therapy for autoimmune liver disease

ZHANG Zhaojie I，2a ， ZHANG Ting ⋅l，2a ， LI Xiangxiang I，2a ， GUO Huijt I，2a ，WANG Zhen ωI，2a ，YANG Meixia ⋅2，2a ，KOU Chunhuan ωI，2a ZHAOYong2b，YUXiaohui ⋅2a ， ZHANG Jiucong²

1.TheFirstClinicalMedicalCollgeofGansu UniversityofChinese Medicine，Lanzhou73ooo，China；2.a.Departmentof Gastroenterology.edicalriceTingCenterh94ospitalofJntLgsticupportFceofAnhon

Corresponding authors： ZHANGJiucong，zhangjiucong@163.com（ORCID：00-03-4006-3033）； ZHAOYong，19692441@qq.com（ORCID：0009-0000-6803-247X）

Abstract：Thepathogenesisofautoimmuneliverdisease（AILD）remainsunclear，leading tosignificantindividualdiferencesin clinicaloutcomes.Recentstudieshaveshowthatintestinalfloraanditsmetabolitesarecloselyasociatedwiththedevelopment， progresion，andpathogenesisofAILDthrough thegut-liveraxis，andtargetedtherapybasedonintestinalflorahasprovidednew strategies forthetreatmentofILD.Thisarticlesystematicallyreviews thepotentialpathogenicmechanismofintestialflorain AILDand thelatestresearchadvances intargetedtherapeuticstrategiesandexplorestheposibilityof targetedregulationof intestinalmicroecologytoachievetreatmentbyanalyzingthemolecularmechanismsofimmunedisordersmediatedbyimbalanceof intestinal flora，inorder to provideatheoretical basis for clinical diagnosis and treatment.

Key Words：Autoimmune Liver Disease； Gastrointestinal Microbiome; Targeted Therapy

Researchfunding：Project of Gansu Provincial Health Care Commission（GSWSKY2023-34）；Lanzhou Youth Scienceand Technology Talent Innovation Project（2024-QN-39）

自身免疫性肝病（autoimmuneliverdisease，AILD）是一类由异常自身免疫反应介导的慢性肝脏炎性疾病，主要包括自身免疫性肝炎（autoimmunehepatitis，AIH）、原发性胆汁性胆管炎（primarybiliarycholangitis，PBC）及原发性硬化性胆管炎（primary sclerosing cholangitis，PSC）。（剩余19534字）