改善铜过载所致线粒体功能障碍防治代谢相关脂肪性肝病的研究进展

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关键词：代谢相关脂肪性肝病；线粒体；铜

基金项目：云南省科技厅中医基础研究联合专项（202301AZ070001-040）；云南省研究生优质课程《医学分子生物学》

Research advances in the preventionand treatment of metabolic associated fatty liver disease by alleviating copper overload-inducedmitochondrialdysfunction

FANG Yutongl，CHEN Yifan’，YANG Xiaomi’，GUO Biyu’，YANG Huiluan’，BAI Yutong'，YAO Zheng I，2，3 （204号

1.SchoolofBasicMedicalSciences，YunnanUniversityofhineseMedicine，Kunming65o5o，China;.YunnanKeyabatory ofIntegratedTraditionalChineseandWesternMedicineforPreventionandTreatmentofChronicDiseases，Kunming650500， China;3.KeyLaboratoryofMicro-dialectics，Yunnan Provincial Collgesand Universities，Kunming 6505o，China

Correspondingauthor：YAO Zheng，yaozhmail@126.com（ORCID：0000-0001-7322-0651）

Abstract：Copperisoneoftheessentialtraceelements inthe humanbodyandparticipates in mitochondrialrespiration，energy metabolism，andantioxidant proceses intheformofcoenzymes orcopper-containing proteins.Intracellacopperaccumulation mainlymanifestsasaboralcopperaccumulationwithinitochondria，leadingtoabnormalitiesinmtochondrialmorpologyand function.thepathologicalprocessofmetabolicassociatedfattyliverdisease（MAFLD）iscloselyassociatedwithmitohondrial dysfunction.StudieshaveconfirmedthatcopperoverloadcanpromotethedevelopmentandprogressionofMAFLD;however，there i stillalackofsystematicsummarzationoftemechanismsbyhichopperoverloadinducesmitochondrialdyfunctionadleads to MAFLDandrelatedadvances indrug research.Inthiscontext，thisarticlereviews theresearchadvances inthemechanisms by which copperoverload induces mitochondrialdysfunctionandleads toMAFLD，aswellasrelatedadvances indrugresearch，in order to provide a theoretical reference for further investigation and treatment of MAFLD.

KeyWords：Metabolic Associated FattyLiverDisease；Mitochondria；Copper

Research funding：YunanProvincial DepartmentofScienceandTechnologyTraditionalChinese Medicine BasicResearchJoint Special Progra（202301AZ070o01-040）； Yunnan Province Graduate High-Quality Course Medical Molecular Biology

代谢相关脂肪性肝病（metabolicassociated fatty liverdisease，MAFLD）是由国际专家小组于2022年提出，用以取代NAFLD（非酒精性脂肪性肝病）的新命名。（剩余20717字）