代谢相关脂肪性肝病肝纤维化的代谢重编程机制

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The metabolic reprogramming mechanisms of liver fibrosis in metabolic associated fatty liver disease

HENYuantongl，DOU Jing²，LI Xue’，SUBINUER Kuerban’，WANG Xiaozhong

1.The FourthClinical Medical Colegeof Xinjiang Medical University，Urumqi830oo，China；2.Departmentof Hepatology， Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region，Urumqi 83oooo，China

Corresponding author：WANG Xiaozhong，wxzl25@sina.com（ORCID： 0000-0002-9389-9232）

Abstract：Therehasbeenagradualincreaseintheincidencerateofmetabolicasociatedfattliverdisease（MAFLD）-relatedliver fibrosisyearbyyearditsprogesionaeventuallleadtoveriosisdeenlivercance.Terearecangesinteatwaysf glucosemetablis，lidetablismdproteetabois，ichrovidceayerppotfothctiatioofatice cells（HSC），therebypromotingtheprogresionofliverfbrosisExistingstudieshavecarifedthespecificmechanismsofmetabolic reprogramminginregulatingtheactivationofHSCsuchastheactivationofHSCandenhancedglycolysis，thefomationofalacticacid microenvironment，the inhibition of fatty acid β -oxidation，the accumulation of lipotoxicity，enhanced glutamine decomposition，and changesinproteiabiltyndSdenosymetioine（S）.reer，thfaiofcticcidmcroeviront，teclation f ipotoxicitydagsieletepresioofveosisisteallvisasi metabolicpathasinMAFrelatedliverfbossnesegisticectbetwntnodertoprovideniporantel basis for revealing the pathogenesis of this disease and developing new treatment strategies.

Key Words： Metabolic Associated Fatty LiverDisease;LiverFibrosis； Hepatic Stelate Cell； Metabolic Reprogramming

Research funding：Natural Science Foundationof Xinjiang Uygur Autonomous Region（2024DolC121）；Open Research Proje（ of the Institute of Science，Xinjiang Medical University（YXYJLSI2O240301）

脂肪性肝病是一类以肝细胞脂肪变性为主要特征的肝脏疾病，临床可分为酒精性肝病（alcoholicliverdisease，ALD）、非酒精性脂肪性肝病（non-alcoholic fattyliverdisease，NAFLD）、继发性脂肪肝、混合型脂肪肝、隐源性脂肪肝以及特殊类型脂肪性肝病[1]。（剩余20808字）