肝内胆管癌局部治疗及系统治疗研究进展
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通信作者：，liuchao3@mail.sysu.edu.cn（ORCID：0000-0001-6659-4372）
基金项目：广州市科技计划项目（2024A04J4776）；中山大学中央高校基本科研业务费专项资金临床研究5010计划资助（2018008）；广州市临床重大技术建设项目（2023P-ZD17）
Research advances in local treatment and systemic therapy for intrahepatic cholangiocarcinoma
LIUYang’，SHI Xiangde²，LIUMingqi²，LIUChao²
1.Departmentof Hepatobiliary Surgery，TheAfliatedHospitalof Guizhou Medical University，Guiyang 55oo0，China;
2.DepartmentoflarceatiurgeryunYsenemoalHospital，unYtenUnersityangoi
Corresponding author： LIU Chao，liuchao3@mail.sysu.edu.cn（ORCID：0000-0001-6659-4372）
Abstract：Intrahepaticcholangiocarcioma（iCCA）isahighlyaggresivemalignanttumorwithporprogosis，anditsicidencate isgraduallyincreasiginrecentyears.ThisarticlereviewsthemainlocaltreatmentmethodsforiCCAandtheadvancesinrelated systemictherapies，withafocusonthecurrent statusofresearchonlocaltreatmentcombinedwithtargetedtherapyand immunotherapy，highlightingtheiradvantagesinimprovingobjectiveresponserateandprolongingprogresion-freesurvivaland overallsurvival.Tisarticlepintsoutthatimmunotherapycombinedwithchemotherapyhasbecomethfirst-linstandardreatment forunresectableiCCA，whiletheregimenoflcaltreatmentcombinedwithtargetedtherapyandimmunotherapyhasshownpromising potentialinclinicaltranslationandsustainedeficacyinearly-phasestudies.Theauthorsbelievethatinthefuture，multicenter prospectivestudiesareneededtoverifythefcacyandsafetyof theabovetreatmentregimen，determinetheoptimalcombined treatmentregimen，nddefinesuitablepatientpopulations，inorder toprovidenewideasforthecomprehensivetreatmentof A.
Key words： Intrahepatic Cholangiocarcinoma；Local Treatment； Systemic Therapy
Researchfunding：Scienceand TechnologyProjects in Guangzhou（2O24A04J4776）；Fundamental Research Funds forthe CentralUniversities，linicalResearch50lProgram，SunYatsenUniversity（O18o8）；MajorClinicalTechnologyProgamof Guangzhou Municipal Health Commission（2023P-ZD17）
肝内胆管癌（intrahepatic cholangiocarcinoma，iCCA）起源于肝内胆管上皮细胞，侵袭力强且预后极差，5年存活率低于 5% 。（剩余31675字）
