胆道恶性肿瘤的免疫治疗现状及研究进展

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DOI：10.12449/JCH251202

通信作者：姜小清，jxq1225@vip.sina.cn（ORCID：0000-0003-2102-4039）

关键词：胆道肿瘤；免疫疗法；治疗学

基金项目：上海市浦东新区卫健委重点学科建设项目（PWZxk2022-02）；上海市浦东新区卫健委卫生计生科技青年科技项目（PW2022B-07）；国家自然科学基金面上项目（82472875）

Immunotherapy for biliary tract cancer： Current statusand research advances

LI Xin’，AO Jianyang²，WANG Jinghan²， JIANG Xiaoqing

1.First Departmentof Biliary Tract Surgery，The ThirdHospitalof Navy Medical University （Eastern HepatobiliarySurgery Hospital），ShanghaiO0438，China；2.InstituteofHepatobiliaryandPancreaticSurgery，DepartmentofHepatobiliarynd PancreaticSurgery，hanghaiEastHospital，TongjiUniversitySchoolofMedicine，hanghaiOo2，ina

Corresponding author： JIANG Xiaoqing， jxq1225@vip.sina.cn （ORCID： 0000-0003-2102-4039）

Abstract：Biliarytractcancer（BTC）isahighlymalignant gastrointestinaltumor withapoorprognosis，anditslimitedtreatment optionsandcomplextumor microenvironenthaveposedsignificantchallnges inclinicaltreatment.Thisarticlesystematically describes thefundamentalfeaturesoftheimmunosupresive microenvironmentinBTCandreviews theroleofimmunecheckpoint inhibitorsinthetreatmentofBTC，aswellasteemergingstrategiessuchascancervaccinesandadoptivecelltransfertherapy Althoughtheimprovementintreatmentoutcomeislimitedbyhightumorheterogeneityandtheimmunosuppresive microenvironment，itisexpectedtoimprovetheprognosisofBTCpatientsbyconstructingabiomarkersystembasedonmultiomics，exploring novel combined treatment strategies，and deeply regulating the tumor microenvironment.

KeyWords：Biliary Tract Neoplasms；Immunotherapy；Therapeutics

Research funding：Key DisciplineConstruction ProjectofShanghai Pudong New Area Health Commision （PWZxk2022-02）; TheYouth Science and TechnologyProjectofShanghai Pudong NewArea HealthCommision（PW2O22B-07）；General Projectof National Natural ScienceFoundation of China（82472875）

胆道恶性肿瘤（biliary tract cancer，BTC）是一种起源于胆管上皮、具有高度异质性的恶性肿瘤，由不同的病理类型组成，包括胆管癌（cholangiocarcinoma，CCA）和胆囊癌（gallbladder cancer，GBC）[1]。（剩余16416字）