整合素在肝纤维化中的作用：从机制到治疗

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Roleofintegrinsinliverfibrosis：Frommechanismtotreatment

SONG Yuyun， YIN Ke，LIU Feng

Peking UniversityPeople'sHospital，PelingUniversityHepatologyInstitute，InfectiousDiseaseandHepatologyCenterofPehing

University People's Hospital，Beijing10oo044，China

Corresponding author：LIU Feng，liul116m@sina.com（ORCID：0000-0002-0316-4938）

Abstract：Liverfibosisisakeypathologicaltageintheprogeionofchonicliverdiseasestoliverciosisandisaracterized byexcessiveextracellarmatrix（ECM）depositionAscriticalmdiatosofcell-CMcotalk，integinsplaynimpoantrolein the development and progression of liver fibrosis.The integrin family includes α and β subunits and is widely involved in the regulationofcelladesion，migration，andsignaltransduction.Intheprocessofliverfibrosis，theexpresionofintegrinsis upregulated，anditsinteracionithECMpromotestheactivationndproliferatinofhpaticstelltecells，furteraceleratgthe synthesisand depositionofECM.Theincreases intheexpressonofintegrinsαVβ3andαVβ6are closelyassociated with the activation of the TGF- β signaling pathway.In addition，integrins also modulate inflammatory responses and tissue regeneration and repairintheliver.Basedontheabove mechanisms，integrinshavebecomethepotentialtargetsforthetreatmentofliverfibrosis， and inhibitors targeting integrins may become a new strategy forthe treatment of liver fibrosis.

Keywords：Liver Fibrosis；Integrins；Hepatic Stellate Cells；Therapeutics

Researchfunding：National NaturalScienceFoundationof China（8217o584）；Beijing Natural Science Foundation（7242151）; Qimin Plan（202308）

肝纤维化是肝脏对慢性损伤的修复反应，不同病因的长期刺激会导致细胞外基质（extracellularmatrix，ECM）过度沉积，并进一步进展为肝硬化甚至肝细胞癌，严重影响患者预后[1]。（剩余19052字）