消化道肿瘤标记物CEA和CA-199比值 对结直肠癌预后的影响

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EffectofCEAandCA-199RatioasGastrointestinal TumorMarkers onthePrognosisof Colorectal Cancer

HOUHuafangl，XIAYanqiu1，ZHANGZhe2，LEIXiao2 （The Second Department of Gastrointestinal Surgery，Department of Traditional Chinese Medicine， Affiliated Hospital of North Sichuan Medical College，Nanchong 637Ooo，Sichuan，China）

Abstract：ObjectiveTostudytheefectofCEA/CA-199（EAR）ontheprogosisofcolorectalcancerpatientswithoralCEAandCA-199 expresioneslaof9oalisilCdeedall HospitalofNorthScanMedicalClgefroJauaryO4tJune16ereaalydretrospectivelyTherelatoshipetweepreatie peripherallodEAleveldlicalseharaceristisfloecalncedspactorogosrealdsultsder theROCcurveUCas588sugestingatERdagostisigificac.eutoffvueofOCurves.524.Thleveoas related to lymph node metastasis P=0 . 0 2 7 ， andtumor size （P=O.Ol6）.Survival analysis showed that the overall survival rate of the low EAR group was lower than that of the high EAR group P=0 . 0 0 6 ） .Univariate COX analysis showed that lymph node metastasis ，distant metastasis P=0 . 0 0 1 ） （204 and EAR expression wereprognostic factors inpatientswithcolorectal cancer.Multivariate COXregressionanalysis showed that distant metastasis（ and EAR expression（ P=0 . 0 3 6 ） were independent prognostic factors affecting the prognosis of patients with colorectal cancer. ConclusionPreoperativeEcanbesedsefereceindeforthergosisfolocaerpatintsialEandCesio Key words：Colorectal cancer；CEA/CA-199；Prognosis

癌症作为全球第2大死亡原因，其死亡例数和发病例数逐年上升。（剩余6977字）