基于FAERS数据库进行伊布替尼药物不良事件信号挖掘

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AdverseDrugEvent SignalsMiningof IbrutinibBased onFAERSDatabase

LIAiguo1，CHENXianglei2

（Department of Blood Transfusion1，Departmentof Hematology2，Yidu Central Hospital of Weifang，

Qingzhou ，Shandong，China）

Abstract：ObjectiveTexplorethedversedrugevent（ADE）sigalsofiutibyusingteFoodandDrugAdminstration（FD）AdvereEvent ReportingSyteERndoovideeferecefolcaltioalgseetdsataofutirthisuartef firstuarteofiedeporigddaofealrogessal wereusedforsignalminingtoaalyzetheoureneofADE.ResultsAtotalof583Oreportsofadverseeventsithbutinibastepriary suspecteddrugeredeedTedauefeseeactiosfiutibs4aysnlyinearlyaofat andADEreportigodnceasingtrendaryaDEigalsre58oling5anasitio（OC）Coio therealworldibsderseetseranduglbelsndlcefochdveseeetsouldmprovdtoeue safety of patients.

KeyWords：Ibrutinib；TheFoodandDrugAdministrationAdverseEventReporting System；Adversedrug event

布鲁顿酪氨酸激酶（bruton tyrosine kinase，BTK）广泛参与B细胞的增殖、分化与凋亡，是恶性血液肿瘤的重要治疗靶点。（剩余8232字）