口腔在幽门螺杆菌感染传播中的地位及作用机制研究

Study on thePosition and Mechanism of Oral Action in the Transmission of Helicobacter pylori Infection/TIANKanglin，HUANGHeyin，MA Fengzhen.//Medical InnovationofChina，2025，22（20）： 177-182

[Abstract] Helicobacterpylori infection iswidespread，with approximately 50% of the global population being infected.The infectionrate is closely related to geographical regions，demographic characteristics，economic conditions，hygiene habitsand the degreeofclosecontact of infected individuals.The infection rate is generally higher in developing countries.Although the transmission routes of Helicobacter pylori have been widely studied， there is a lack of direct evidence for its recognized transmission routes.More and more evidence shows that oralcavity maybe the mainrouteof transmission，butthe position androle oforal cavityin transmisionis still inconclusive.This review aims tooutline the potential positionand mechanism of action of theoral cavityin the transmissionofHelicobacterpylori，withtheexpectationof providingnew ideas fortheblockingof Helicobacterpylori transmission.

[Keywords] Helicobacter pylori Oral cavity Infection mechanism Mechanism of transmission

First-author'saddress：DepartmentofGeneralMedicine，Binzhou Medical UniversityHospital Binzhou 256603， China

doi：10.3969/j.issn.1674-4985.2025.20.041

幽门螺杆菌与胃癌的发生高度相关，中国胃癌发生率及死亡率均占到了全球的 40% 以上，严重威胁人民健康。（剩余15322字）