妊娠期糖尿病患者血清25-（OH）D、FA、 VB12 含量对并发子痫前期的评估价值
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EvaluationValueofSerum25-（OH）D，FAandVitamin B12 Contentsin PatientswithGestational Diabetes Melitus for Predicting Concomitant Preeclampsia/WENG Taihuan.//Medical Innovation of China，2025，22（20）：149-153
[Abstract] Objective： The analyze the evaluation value of serum 25-hydroxyvitamin D [25-（OH）D]， folic acid （FA） and vitamin B12 0 VB12） contents in patients with gestational diabetes melitus （GDM） for predicting concomitant preeclampsia （PE）.Method： A total of 8O patients with GDM who underwent regular prenatal examinationsat Shangrao Maternaland Child Health Hospital from January2O21 to March 2O24 were selectedas theresearch subjects，and were divided into the PE group and the non-PE group according to whetherthe patients were complicated withPE，with 33 and47cases in each group.The baseline data and the levels of25-（OH）D，FA andVB 12 of the two groups were compared. The influencing factors of GDM patients complicated with PE were analyzed bymultivariatelogistic regression，and 25（OH）D，FA and VB12 were analyzed by ROC curve to evaluate the efficacy of GDM patients complicated with PE.Result： The levels of 25-（OH）D，FA and VB 12 in the PE group were significantly lower than those in the non-PE group（ P <0.05）. 25-（OH）D， FA and VB 12 were independent influencing factors for concomitantPE in patientswith GDM（ P <0.05）.ROC curve analysis showed that the AUC of 25-（OH）D， FA and VB 12 in evaluating concomitant PE in patients with GDM were 0.765，0.792，and O.831，respectively，the sensitivities were 78.79% ， 87.88% ，and 78.79% ，respectively，and the specificities were 70.21% ， 61.70% ，and 78.72% ，respectively.Among them，the sensitivity of FA was the highest，and the specificity of VB12 was the highest.
Conclusion：25-（OH）D，FA and VB12 allhave high evaluation efficacy for patientswith GDMcomplicated with PE. [Keywords] Gestational diabetes melitus25-hydroxyvitaminD Folic acid Vitamin B12 Preeclampsia First-author'saddress： Department of Obstetrics，Shangrao Maternal and Child Health Hospital，
Shangrao 334000， China doi：10.3969/j.issn.1674-4985.2025.20.035
妊娠期糖尿病（GDM）是一种特殊的糖尿病类型，在妊娠24＼～28周通过筛查确诊。（剩余6025字）
