阿托伐他汀钙联合阿司匹林对颈动脉狭窄 患者脑血管血流参数及IMT的影响

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Effect of Atorvastatin Calcium Combined with Aspirin on Cerebrovascular Blood Flow Parameters and IMT inPatients with Carotid Stenosis/SU Yanling，DAI Li，WANGJingyi，PAN Xuefen，GAN Huizhen.//MedicalInnovationofChina，2025，22（20）：104-108

[Abstract] Objective：To investigate the effect of Atorvastatin Calcium combined with Aspirin on cerebrovascular blood flow parametersand carotid intima-media thickness（IMT） in patients with carotid stenosis （CS）.Method：A totalof90 patients with CSwho admited to the 91Oth Hospital of the JointLogistics Support Force of the ChinesePeople's Liberation Armyfrom June2O21 to June 2O23 were included，andthey weredivided into the control group （ n =45）and the observation group （ n =45） by random number table method. Two groupswere given routine treatment，thecontrol group was treated with Aspirin，and the observation group was treated with Aspirin combined with Atorvastatin Calcium，two groups were treated for 3 months.The cerebrovascular blood flow parameters[middlecerebral artery end-diastolic peakvelocity （EDV），peak systolicvelocity（PSV），resistance index（RI），mean bloodflowvelocity （Vm），leftandrightcarotidarteryand internal arteryIMTwerecompared between two groups before and after treatment，and the adverse reactions were compared.Result： After treatment， the EDV，PSVand Vm of two groups were increased，and those in the observation group were higher than those in the control group，theRI，IMTof right and left common carotid arteries and internal arteries of two groups were decreased，and those in the observation group were lower than those inthe control group，the difference was statisticallysignificant （P<0.05） .There was no significant difference in the incidence of adverse reactions between twogroups（ P>0.05 ）.Conclusion：Atorvastatin Calcium combined with Aspirin applied in patients with CS can improve cerebrovascular blood flow parameters，reduce IMT，and has a certain security.

[Keywords] Carotid stenosisAspirin Atorvastatin Calcium Cerebrovascular blood flow parameters Carotid intra-arterial middle thickness

First-author'saddress：Department ofPharmacy，the 91oth Hospital of the Joint Logistics Support Forceof theChinesePeople'sLiberationArmy，Quanzhou362ooo，China doi： 10.3969/j.issn.1674-4985.2025.20.024

颈动脉狭窄（CS）是血管外科常见病，主要由颈动脉发生狭窄导致，高血压也是常见诱因。（剩余5067字）