2型糖尿病合并失眠患者血清ICAM-1、ox-LDL、 VEGF水平变化及临床意义

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【关键词】2型糖尿病；失眠；细胞间黏附分子1;氧化型低密度脂蛋白；血管内皮生长因子中图分类号：R587.2 文献标志码：A DOI：10.3969/j. issn. 1003-1383.2025.07.008

【Abstract】ObjectiveToanalyze thecharacteristicchanges intheserum levelsof intercellularadhesionmolecule-1 （ICAM-1），oxidized low-density lipoprotein（ox-LDL），andvascular endothelial growth factor（VEGF）inpatients with type2diabetes melltus（T2DM）complicatedbyinsomnia，soas toexploretheirclinicalsignificance.MethodsAtotalof 108 T2DMpatients admitted toahospitalfrom May2O21 toMay2022 wereenrolled.According to thePitsburgh SleepQuality Index（PSQI） score，they were divided into non-insomnia group （PSQI≤7 points， n=53 ）and insomnia group （PSQI> 7points， n=55 ）.General clinical characteristics，glucose and lipid metabolism indexes，and serum levels of ICAM-1， ox-LDL，and VEGF were compared between the two groups，and correlations between PSQI total scoreand theabove-mentionedindicators were analyzed.ResultsThe insomnia groupshowedsignificantlyhigherlevelsof systolic bloodpressure （SBP），fasting insulin（FINS），homeostasismodelasessment-insulinresistance（HOMA-IR），glycosylated hemoglobin （HbA1c），and total cholesterol（TC）than the non-insomnia group（ P<0. 05 ）.SerumICAM-1（4 .83ng/mL vs （2 3.18±0.60ng/mL ）and ox-LDL （ 14.02±4.75μg/mL vs 9.97±4.05μg/mL ）levels in the insomnia group were significantly higher than thosein the non-insomnia group （all P<0.05 ），whereas the difference in VEGF levels between the two groups was not statistically significant （ P>0.05 ）. Pearson correlation analysis revealed that the PSQI total score was positivelycorrelated withICAM-1（ r=0.52 ）and ox-LDL（ r=0.46 ）（all P<0.05 ）.Conclusion Serum ICAM-1 and ox-LDL levelsare significantlyincreased inT2DMpatients with insomnia，sugestingthatinsomniamaypromote theoccurrenceand development of diabetic microvascular complications by exacerbating inflammatory responses and oxidative stress.

【Keywords】type2 diabetes melltus（T2DM）；insomnia；intercellularadhesionmolecule-1（ICAM-1）；oxidized low-density lipoprotein（ox-LDL）；vascular endothelial growth factor（VEGF）

失眠是最常见的睡眠障碍形式，其特征是尽管有充足的睡眠机会和适宜的睡眠环境，但仍存在频繁而持续的入睡困难、睡眠维持障碍，以及对睡眠时间和/或质量的不满[1]。（剩余5268字）