基于网络药理学探讨红景天防治阿尔茨海默病的作用机制

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中图分类号：R749. 1+6 （2 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.07.003

【Abstract】ObjectiveTo investigate the active componentsand mechanism of Rhodiola rosea L.in the preventionand treatmentofAlzheimer'sdisease（AD）bynetworkpharmacology.MethodsThemainefectivecomponentsof Rhodiola roseaL.werecollectedbyCNKI，andthepotentialtargetsofRhodiolaroseaL.were predicted bySwistargetprediction. Therelated targetsof ADwere screenedby Genecards，OMIMand NCBI databases.The intersection of Rhodiolarosea L. and AD targets was obtainedby Venny2.1.O.Theproteininteraction network wasobtained byusing STRING database.A component-target-disease interaction network was constructed through Cytoscape3.7.2.Finally，gene ontology（GO）analysis and Kyoto encyclopedia of genesand genomes （KEGG）pathway enrichment analysis were performed via the DAVIDdatabase.ResultsFromRhodiolaroseaL.，28chemicalcomponents，846targetsand226AD-relatedtargetswereidentified， witha totalof119 intersecting targets betweenchemical componentsandAD.The protein interactionnetwork center mainly involved key targets such as GAPDH，TNF，AKT1，EGFR，STAT3，MMP9，and SRC，etc.The KEGG signaling pathway analysismainlyinvolved HIF-1 signaling pathway，cancer signaling pathway and PI3K-Akt signaling pathway.Conclusion Rhodiola rosea L. may play a role in treating AD by acting on multiple targets and multiple signal pathways.

阿尔茨海默病（Alzheimer'sdisease，AD）是一种与老化相伴的神经系统退行性疾病，其特征是神经细胞的广泛损耗，进而严重损害个体的记忆与认知功能，严重时甚至影响患者的基本生活自理和生理功能直至死亡[1-2]。（剩余11749字）