血液代谢物与脑梗死的因果关系：一项两样本双向孟德尔随机化研究

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中图分类号：R743.33 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.07.004

【Abstract】ObjectiveTo explore thecausal relationship between blood metabolitesandcerebral infarction（CI）by two-sample two-way Mendelian randomization（MR）analysis.MethodsThe published genome-wide asociation studies （GWAS）dataof cerebral infarction were obtained from public database.Witha GWAScontaining 140O circulating metabolitesas an exposure indicator，SNPswhich stronglyrelated to exposure factors wereselected as instrumental variables （IV）. Thecausalrelationshipbetween140ObloodmetabolitesandcerebralinfarctionwasanalyzedbyR4.3.2software.Fivemethods—MR-Egger regresson，inverse-variance weighted （IVW），weighted median，simple mode，and weighted mode—were employedtoasessheterogeneity，pleiotropy，andsensitivity，therebyverifying therobustnessoftheresults.Finall，a reverse MRanalysis was performedon theobtained results.ResultsIVW method was used to assess causal relationship betweenblood metabolitesand CI，and the results showed that urea （OR=0.997，95%CI： 0.996-0.999）wasa protectivefactor，andtheriskofCIdecreasedwiththeincreaseofmetaboliteurea.ThereverseMRresultsshowedthattherewas nocausalrelationshipbetweenthediseaseandthe metabolites.ConclusionUreahasaninhibitoryefectoncerebral infarction，which may providenewideas and newbasis fortheclinical treatmentand scientificresearchofcerebral infarctionin the future.

【Keywords】metabolites；cerebral infarction（CI）；Mendelian randomization（MR）；urea

脑梗死（cerebralinfarction，CI）是指一系列脑血管疾病导致脑部供血障碍，局部脑组织缺血、缺氧坏死，进而损害神经功能，甚至发生偏瘫等严重后果的一类临床综合征[。（剩余5500字）