线粒体自噬在糖尿病心肌病中的作用及其研究进展

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【关键词】线粒体自噬;糖尿病心肌病；糖尿病;线粒体质量控制;降糖药物 中图分类号：R587.2 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.07.001

【Abstract】 Diabeticcardiomyopathy（DCM）isanon-ischemic，non-hypertensivemyocardial disorder induced bymetabolic disturbancesinpatientswitabeteselltus（D），nditsignficantlyaectsprogosisndmortalityAstecentraloranellfor celularnergymetabolism，mitochondrialdysfunctionrepresentsakeypathologicalmechanisminDCM.Mitophagy，asaritical componentofmitochondrialqualitycontrol，laysadualregulatoryroleinDCMprogresionbyselectivelyremovingdamagedordysfunctionalmitochondria.Tiseviewsystematicallsummarizesthemolecularmechanismsofmitophagy，includingubiquitin-dpedent pathways （PINK1/Parkin pathway），receptor-mediated pathways（FUNDC1，BNIP3/NIX，PHB2，etc.），and pathways mediated by TFEB/calcineurinItalsoexploresthiroesinDCM（suchastime-dependentchanges inutopagyinHFDmodels，potentialdetrimental ffectsofenhancedautopagyinTD）andsynthesizesresearchprogressonhowantidiabeticdrugs（empagliflozin，liraglutide，meformin，etc.）improveDCMthroughmitophagyregulation.Elucidating theregulatorymechanismsandtargetedintervention strategiesof mitophagymayprovidenoveltheoretical foundationsandtherapeuticdirections forDCMpreventionandtreatment.

【Keywords】mitophagy；diabeticcardiomyopathy（DCM）；diabetes melltus（DM）；mitochondrialqualitycontrol;antidiabeticdrug

糖尿病（diabetesmellitus，DM）是一种因糖代谢紊乱导致葡萄糖利用障碍的高血糖症[1]。（剩余12956字）