琥珀酰化在肿瘤发生发展中的作用机制研究进展

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esearch progress on the mechanism of succinylation in tumorigenesis and development

Su Xiayi1'²，Bai Jie1，³，Zhang Baihong¹，Liu Yong² （20号 1 The940thHospitalofJintLgsticsSupportForceofPeople'sLiberationAryLanzhou73oO；²DepartmentofMedicine，orthest MinzuUniversity，Lanzhou3O3o；theFirstchoolofClinicalMedical，GansuUniversityofChinseMedicine，Lanzhou0000 **Corresponding author；Liu Yong，email：yliu668 @ 126. com

[Abstract]Succinylationisapost-translationalmodificationprocessthatplaysacrucialroleinregulatingproteinstructure andfunctionandisimplicatedinthepathogenesisofvariousdiseases.Emergingevidencesugeststhatsucinlationcontributesto tumorprogresionbymodulating metabolicreprogrammingandinfuencingtheexpresionof targetproteingenes.Thesealeratioscan significantlyimpacttumordevelopmentandprogresio.Tiseviewimstosummarizethemechanisticoleofsuccylationinorgenesis，providing insights into itspotential asa biomarker forcancer diagnosisandatargetfortherapeutic intervention.

[Key words] Succinylation modification；Metabolic reprogramming；Tumor；Targeted therapy；Post-translational modification

翻译后修饰（Post-translational modification，PTM）是对翻译后蛋白质中氨基酸侧链的共价修饰，可通过调控蛋白质的折叠、活性、稳定性、定位、信号传导和结合来扩大蛋白质功能的多样性[1]。（剩余9772字）