神经内科ICU住院病人多重耐药菌的病原学特点及危险因素

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Pathogenic characteristics and risk factors of multi⁃drug resistant organism in hospitalized patients in neurology ICU

LU Xiaoyun1， ZHANG Yinping2， SHEN Li1， SUN Huiying1， ZHANG Pengliang1， YANG Zhaoxu1*

1.The First Affiliated Hospital of Air Force Military Medical University， Shaanxi 710032 China；2.Xi'an Jiaotong University

*Corresponding Author  YANG Zhaoxu， E⁃mail： 15829057616@163.com

Abstract  Objective：To analyze the pathogenetic characteristics of multi-drug resistant organism（MDRO） and the risk factors for their occurrence in patients hospitalized in neurology intensive care unit（ICU），and to provide a theoretical basis for the prevention and control of MDRO in neurology ICU.Methods：1 003 patients hospitalized in the neurology ICU of a tertiary grade A hospital from January 1，2019 to December 31，2022 were retrospectively analyzed，and the risk factors of MDRO were detected using logistic regression analysis.Results：MDRO were detected in 363 patient cases，with Acinetobacter baumannii［274 strains（51.41%）］ predominating，followed by Klebsiella pneumoniae［92 strains（17.26%）］ and Staphylococcus aureus［85 strains（15.95%）］.And Acinetobacter baumannii ranked No.1 in terms of the detection rate for the fourth consecutive year；the specimens were mainly distributed in sputum（82.55%），followed by urine（15.20%）；the site of hospital infection of MDRO was mainly in the lower respiratory tract.Results of logistic regression analysis showed that the number of days of antibiotic use，leukocyte count，and indwelling urinary catheter were the influencing factors of MDRO detected in neurology ICU patients.Conclusion：Neurology ICU patients with complex conditions and long duration of illness are prone to detect MDRO.And the precise formulation of preventive measures according to the pathogenetic characteristics of MDRO and the risk factors for their occurrence，which can help to reduce the rate of MDRO infections and improve the effectiveness of diagnosis and treatment.

Keywords  neurology ICU； multi⁃drug resistant organism； pathogenetics； risk factors

摘要  目的：分析神经内科重症监护室（ICU）住院病人多重耐药菌（MDRO）的病原学特点及发生的危险因素，为神经内科ICU的多重耐药菌防控提供依据。（剩余8943字）