糖基化对电压门控型钾离子通道作用的研究进展

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关键词：电压门控型钾离子通道；糖基化；心律失常；癌症；神经系统疾病 中图分类号：R3.34文献标志码：A 文章编号：1001-5779（2025）09-0908-09 DOI：10.3969/j.issn.1001-5779.2025.09.016

Abstract：Glycosylation，asanimportantpost-translational modificationof proteins，regulatesneuronal excitability， cardiacelectrophysiology，andotherproceses byinfluencing the structure，function，and membranelocalizationof voltage-gated potassium channels （ Kv ）.In recent years，studies have found that the addition or loss of specific glycans （such asN-glycans and O-glycans）can significantlyalter the membrane localization，protein stability，gating properties， anddrugsensitivityofKvchannels.Moreover，thecorrlationbetweenabnormal glycosylationlevelsofKvchannelsand diseases，such asarhythmia，cancer，andneurological disease，has been increasinglyrevealed.This review summarizes the maintypesof glycosylationand the impactof glycosylationonthe functionof Kvchannels，andalso explores he relationship between glycosylation of Kv channels and related diseases，aiming to provide new insights for the research and treatment of related diseases.

Key Words：Voltage-gated potassiumchannels；Glycosylation；Arrhythmias；Cancer；Neurological diseas

电压门控型钾离子通道（Voltage-gated potassiumchannels，Kv是一类对膜电压变化高度敏感的钾离子通道亚型，其在调控细胞生理功能和信号传递等生理过程中扮演着重要角色。（剩余18405字）