芒果苷脂质体的制备与表征

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中图分类号：R94 文献标志码：A 文章编号：1001-5779（2025）09-0825-05

DOI：10.3969/j.issn.1001-5779.2025.09.001

Abstract：Objective：To screen the preparation methodand theoptimalprescription of mangiferinliposomes.Methods： Theaverageparticle size，polydispersity index （PDI），and Zeta potential were used as evaluation indicators.The L9（34） orthogonal experiment wasconducted to determine theoptimal prescriptionand preparationmethodof mangiferin liposomes.The prepared mangiferin liposomes withtheoptimal prescriptionand preparationmethod were characterized， andtheentrapment efficiency was determined byhigh performance liquid chromatography.Results：The optimal prescription was DOTAP ：cholesterol：sunflower phospholipid ：mangiferin =2：6：1.5：1 （molar ratio），and the filmhydration methodwasthebest forthepreparationof the liposomes.Theaverageparticlesizeofthe product was （182. 20±2.25 ）nm，the PDI was （ 0. 148±0. 001 ），and the Zeta potential was （ 45.70±0.56 ） mV . The morphology of the mangiferin liposomeswas nearlyspherical underscanning electron microscopy.The entrapment eficiency was 93.85% .Conclusion：The prepared mangiferin liposomes hadasmall average particle size，a uniform and stable liposome system，and a nearly spherical morphology，which met the standards of liposomes.

Keywords：Mangiferin;Liposomes;Preparation

芒果苷是一种天然多酚类化合物，广泛存在于知母、芒果果实、漆树科及鸢尾科植物中[1]。（剩余6488字）