间断洗胃联合反复血液灌流治疗急性重度有机磷药中毒患者的临床疗效评估

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中图分类号：R459.7 文献标志码：A 文章编号：1001-5779（2025）09-0847-05

DOI：10.3969/j.issn.1001-5779.2025.09.004

Abstract：Objective：Toevaluate theclinicaleficacyof intermitent gastriclavagecombinedwithrepeatedhemoperfusion inthe treatment of patients with acute severe organophosphorus pesticide poisoning.Methods：A total of 94 patients withacutesevereorganophosphoruspesticidepoisoningadmitedtotheFirstAfiliatedHospitalof GannanMedical University from October2O15to October 2O23 were selectedastheresearchsubjects.They were divided into the treatmentgroupandthecontrol groupaccording to thetreatmentmodality.Thetreatment groupwas treatedwith intermitent gastriclavagecombined withrepeated hemoperfusion，whilethecontrol group was treated with singlegastric lavage.The impactofthetreatmentmodalityonthehospitalizationtime，dosageofatropineandpralidoxime，durationandrequirement of mechanical ventilation，mortalityrate，and incidence of pulmonary infection andrespiratoryfailure was analyzed using multiple linearregressionand logisticregression.Results：Significant diffrences wereobserved betweenthe two groups intermsof thehospitalization time，atropine dosage，duration of mechanicalventilation，requirement for mechanical ventilation，and incidence of pulmonary infection（ P<0.05 ）.However，after adjusting for the confounding factor of vasoactivedruguse，thedifferences inthe hospitalization timeand incidenceof pulmonary infection wereno longer statisticallysignificant （ P>0.05 ）.Conclusion：Intermittent gastric lavage combined with repeated hemoperfusion can significantlyshortenthelengthofhospitalstayandreducetheincidenceof pulmonaryinfectioninpatientswithacute severeorganophosphorus pesticide poisoning.Itisan efectivetreatment planto improvetheprognosis ofsuch patients， butitslong-term impact onmortality still needs tobe further verifiedbylarge-sample studies.

KeyWords：Organophosphatepesticidepoisoning；Gastric lavage；Hemoperfusion；Multivariateregresionanalysis; Clinical efficacy

有机磷化合物是一类含磷的有机化合物的总称，主要作为农药广泛应用于农业生产中[]。（剩余6658字）