T淋巴细胞在慢性阻塞性肺疾病发生发展及免疫治疗中的作用

关键词：肺疾病，慢性阻塞性；T淋巴细胞；免疫治疗

中图分类号：R563.9文献标志码：A文章编号：1001-5779（2025）05-0485-07

DOI：10.3969/j.issn.1001-5779.2025.05.013

Abstract：Tlymphocytes playa keyrole in the occurrence and developmentof chronic obstructive pulmonary disease （COPD）. They are classified into CD 4+ Tlymphocyte subsets and CD8+T lymphocyte subsets according to the expression of clusterofdiferentiation（CD），which mediate inflammatoryresponses and participate in immuneregulation processes in COPDthroughthesecretionofcytokines.WhentheproportionofTcellsubpopulationsisimbalanced，itcanlead to immuneimbalance andaggravate lung tissue damage.Currently，Tlymphocyte-related immunotherapyfor COPD mainly focuseson anti-inflammation and immune regulation，including intervention measuressuch as monoclonal antibodies， vaccines，andchemicalagents.Thisarticlemainlyreviews theroleofTlymphocytes intheoccurrenceanddevelopment of COPD and in immunotherapy，aiming to provide a new theoretical basis for clinical treatment.

Keywords：Pulmonary disease，chronic obstructive；Tlymphocytes；Immunotherapy

慢性阻塞性肺疾病（Chronicobstructivepulmo-narydisease，COPD）是以持续性气流受限为主要特征的慢性呼吸道疾病，常表现为持续性的呼吸道症状[]。（剩余18538字）