赖氨酰氧化酶家族在肿瘤发生发展中的复杂作用

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关键词：赖氨酰氧化酶；肿瘤；复杂作用

中图分类号：R34；R730.23文献标志码：A 文章编号：1001-5779（2025）05-0476-09

DOI：10.3969/j.issn.1001-5779.2025.05.012

Abstract：The lysyl oxidase （LOX）familycomprises secreted copper-dependent amine oxidases that plays a crucial role infacilitatingthecovalencross-lnkingofcollgenandelastin，therebypromotingtheformationofacross-linkingnetwork withinthe extracelular matrix（ECM）and maintaining its normal structure and function.Studies have suggested thatthe proteins belonging to the LOX familyare involved in shaping the tumor microenvironment prior to metastasis through various signaling pathways，exerting eitherpromoting orinhibiting effectsontheproliferation，invasion，andmigrationof tumor cells，which underscores their significantrole in theonsetand progression of various tumors.This makes the LOX familyapotentialtargetfor tumor diagnosisand treatment.Thisarticleaims toreviewthe expressonand underlying mechanismsoftheLOX familyintumors，enhancing ourunderstandingof thecomplexrolesoftheLOXfamilyin tumor progression and providing a reference for tumor monitoring and treatment.

KeyWords：Lysyl oxidase;Tumor；Complexroles

赖氨酰氧化酶（Lysyloxidase，LOX）是由细胞分泌的、作用于细胞外基质（Extracellularmatrix，ECM）胶原和弹性蛋白的赖氨酸残基从而产生分子交联的一种胺氧化酶。（剩余17904字）