抗氧化基因1与神经退行性疾病：从分子机制到靶向药物研究

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中图分类号：Q754 文献标志码：A 文章编号：1001-5779（2025）05-0424-05

DOI：10.3969/j. issn. 1001-5779.2025.05.002

Abstract：Oxidationresistance gene1（OXR1），asan evolutionarilyconserved endogenousantioxidant defense system coreregulator，playsakeyroleinmaintainingcellularredoxhomeostasis.Studies haveshown that OXR1canbuildamultilevelantioxidantdefensenetwork toprotectcelsfromoxidativedamagebyregulatingantioxidant pathways，maintaining mitochondrial function，and stabilizing thereverse transport complex.Theabnormal expresson ofOXR1is closely related totheoccurrenceanddevelopmentofoxidativestress-relateddiseases （suchasneurodegenerativediseases，cardiovasculardiseases and malignant tumors），butthe mechanism of action is complex.This article reviews the structure， function，role，andpharmacologicalresearchofOXR1，providingatheoreticalbasis forunderstandingitsinvolvementin neurodegenerative diseases and the development of OXR1-targeting drugs.

Key Words： Oxidation resistance gene 1； Neurodegenerative diseases；Oxidative stress；Reactive oxygen species

氧化损伤是机体在生理或病理条件下，活性氧（Reactiveoxygenspecies，ROS）过度累积引发的分子级联反应，通过破坏脂质、蛋白质及核酸等生物大分子，诱发细胞功能障碍甚至死亡[1。（剩余10718字）