基于网络药理学研究苦刺花提取物防治肺结节的作用机制

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关键词：肺结节；苦刺花提取物；网络药理学；药理作用；分子作用机制中图分类号：R28;R563文献标志码：A 文章编号：1001-5779（2025）05-0417-07DOI：10.3969/j.issn.1001-5779.2025.05.001

Abstract：Objective：To predictthe mechanismof the Sophoradavidi flower extract（SDFE）in preventing and treating pulmonary nodules based on network pharmacology.Methods：The SwissTarget Predictionand GeneCards databases wereusedtoobtainthetarget genes ofcompounds in SDFEandthe therapeutic targetsfor pulmonarynodules，respectively， follwed byidentifying their intersection targets.The STRINGonline platform was employed toconstructaprotein-protein interaction （PPI） networkof theintersectiontargets.GOand KEGG enrichmentanalyses were performedontheintersection targetsusing theDAVID database.Acompound-intersection target-KEGG networkwas constructed using Cytoscape software，and molecular docking validation was conducted using Discovery Studio software.Results：92 intersection targetswere determined.GO functional enrichment analysis revealed thatthese targetswere primarily associatedwith transmembrane receptor protein tyrosine kinaseactivity，positive regulationof kinaseactivity，andreceptorcomplexes. KEGG enrichment analysis indicated significant involvement in pathways in cancer and PI3K-Akt signaling pathway.The commoncore targets inboth thePPI networkandthecompound-intersectiontarget-KEGG network were EGFR，MMP9， SRC and AKT1.The top10core compounds were palmatine，medicarpin，genkwanin，pinocembrin，7-methoxyluteolin， nepetalactone，naringenin，diosmetin，luteolinand matrine.Moleculardocking results showedthatluteolinandmatrine hadLibDockScores greater than10O whenbinding to core targets such as EGFR，MMP9 and SRC.Conclusion：SDFE canprevent and treatpulmonary nodules through multiplecomponents，multiple targets and multiplepathways，providing a theoretical basis for subsequent experimental validation and drug development.

KeyWords：Pulmonarynodules；Sophora davidii flower extract；Network pharmacology；Pharmacological action; Molecular mechanism of action

肺结节是指肺部小的、局限性的、近圆形的病灶，通常直径 <3cm 。（剩余9160字）