胶质母细胞瘤的糖代谢分子机制及其靶向治疗的研究进展

【中图分类号】 R739.41 【文献标志码】 A 【文章编号】 1672-7770（2025)05-0594-07

Research progres on molecular mechanism of glucose metabolism and targeted therapy for glioblastoma SUN Yi，JIN Wei，NI Hongbin，DAI Yuxiang，ZHOU Lu，YAN Huiying，YIMURAN Yilamu，MAO Jiannan，YAN Chaolong.Department of Neurosurgery，Nanjing Drum Tower Hospital，Clinical Colege of Nanjing Medical University，Nanjing ,China

Corresponding author : JIN Wei

Abstract:Glioblastoma(GBM） is the most aggressive malignant tumour among gliomas，and the mechanism of its malignant progression isstill unclear.GBM hasits ownunique immune microenvironment（TME）and glycometabolicfeatures，leading tosignificant heterogeneityandmetabolicplasticityof tumourcels.Theeffcacyof single-targetdrugs is limited.Glycolytic metabolism transcriptionalregulators and epigeneticalterations are aociated withitsoccurrenceandprogresion，whilerelatedmetabolicpathwaysandtargetsprovidepotential positive implications for thedevelopmentof novel therapeuticapproaches.Theaimof this reviewis to summarize thecurrent newtargeted therapeutic approaches and ideas for the treatment of GBM.

Keywords: glioblastoma； tumour metabolic reprogramming；epigenetic and molecular mechanism; argeted therapy

胶质母细胞瘤（glioblastoma，GBM）是中枢神经系统中最常见且最具侵袭性的原发性恶性肿瘤，其标准治疗方案包括手术切除、放疗和替莫唑胺化疗，但患者中位生存期仍不足15个月,预后极差[1]。（剩余22476字）