基于生物信息学分析的脑出血后癫痫分子机制及潜在治疗靶点研究

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【中图分类号】R742.1【文献标志码】A【文章编号】1672-7770（2025）05-0492-07

Molecular mechanisms and potential therapeutic targets of post-intracerebral hemorrhage epilepsy ： a bioinformatics analysis LI Pengpeng，LI Miaobo， GAO Yangyang， LU Xiaojie， ZHAO Xudong，ZHOU Yiting. Department of Interventional Radiology，Afiliated Hospital of Jiangnan University，Wuxi 214122，China

Corresponding author： ZHOU Yiting

Abstract： Objective To investigate the molecular mechanisms of post-intracerebral hemorrhage （ICH）epilepsy and screen for potential therapeutic targets and small-molecule drugs.MethodsGene expression data for ICH（GSE24265） and epilepsy（GSE168375） were integrated from the GEO database. Differentially expressed genes （DEGs）assciated with post-ICH epilepsy were screened through differential expression analysis and subjected to functional enrichment analysis. A protein-protein interaction（PPI）network was constructed to identify core functional modules andgenes.The Connectivity Map（CMAP） database was used to predict potential small-molecule drugs. ResultsA total of 60 post-ICH epilepsy-related DEGs were identified，which were primarily enriched in processes such as inflammatory response，coagulation abnormalities，and intercellular signaling.PPI network analysis identified a core functional module containing 14 genes，involved in fibrin clot dissolution，regulationof leukocyte adhesion，and response to cytokine stimulation. CMAP analysis screened five potential antiepilepticsmall-moleculedrugs： CCT-O18159， mometasone， vanoxerine， methocarbamol，and carbenoxolone.ConclusionsThe occurrence of post-ICH epilepsy is closely related to abnormalities in multiple pathways including inflammation，coagulation，and celladhesion.The identified core genes and small-molecule drugs provide new targets and directions for its precise treatment.

Keywords： post-intracerebral hemorrhage epilepsy；bioinformatic；differentially expressed gene；protein-protein interaction network；small-molecule drug

脑出血（intracerebralhemorrhage，ICH）作为全球范围内第三大致死性疾病一卒中的重要亚型，其临床危害性不容忽视[1]。（剩余9392字）