促红细胞生成素改善创伤性脑损伤后继发性神经损伤的作用机制研究进展

打开文本图片集

【中图分类号】 R651.1 【文献标志码】 A 【文章编号】 1672-7770（2025）05-0583-05

Advances in mechanism of erythropoietin in improving secondary neural damage after traumatic brain injury LI Dongyang， WANG Zhongan， YANG Hua，LIU Jinhui， TANG Xianyong. Department of Neurosurgery，the First People's Hospital of Qingzhen City，Qingzhen ，China

Corresponding author： WANG Zhongan

Abstract：Traumaticbrain injury（TBI）isoneof thesignificant causes of mortalityand disability worldwide.It is characterized bymechanical damage to thebraincaused by external impact，which mayresult in irrversible harm tofunctional neurons.Thecascadeofreactions initiatedbysecondaryinjuryisoneof theprimaryfactors leading to neural functional impairmentandtheelevationofoxidative stressand inflammatorylevels.Erythropoietin（EPO），asa typeIcytokine，mitigatessecondary neuronal injurythrough multi-targetneuroprotective mechanisms，representing a highlypromising therapeuticstrategyforTBI.However，itsclinical translation stillneeds toaddresshematopoietic sideeffectsand delivery efciency bottlenecks.Thisreview summarizes theresearch progress on exogenousEPO administrationin TBI treatment.

Key words： traumatic brain injury；erythropoietin；oxidative stress；inflammatory response；blood brain barrier；neuroprotection

创伤性脑损伤（traumaticbraininjury，TBI）是全球高死亡率及致残率的主要原因，目前仍缺乏有效药物干预[1-2]。（剩余12948字）