电压门控钙通道在脑血管疾病中的作用机制研究进展

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【中图分类号】 R743 【文献标志码】 【文章编号】 1672-7770（2025)05-0588-06

Research progress on the role and mechanisms of voltage-gated calcium channels in cerebrovascular diseases HUANG Tianci， ZHAO Jinbing，ZHANG Guangxu， QIU Cheng，CHEN Lijiu，MA Jun. Department of ，Brain HospitalAfliatedto ，210o29， Corresponding author : MA Jun

Abstract: Cerebrovascular diseases are a major global public health concern owing to their high incidence, mortality，and disabilityrates.Calcium ions，ascrucial intracellularsignalingmolecules，regulate various physiological processes via calcium channels,including vascularsmooth muscle contraction，neurotransmiterrelease, and neuronal excitability.Thisreviewsummarizes theclassificationand functionsof voltage-gatedcalcium channels, with a focus on their rolesand mechanisms in ischemic cerebrovascular disease，subarachnoid hemorhage，vascular dementia，and moyamoya disease.

Key words：calcium ions；voltage-gated calcium channel；ischemic cerebrovascular disease；subarachnoid hemorrhage；vascular dementia；moyamoya disease；calcium channel blockers

脑血管疾病是严重威胁人类健康的重大疾病之一，在全球死亡原因中排名非常靠前，仅次于缺血性心脏病1]。（剩余17735字）