基于T2WI超分辨率重建影像组学对前列腺癌包膜外侵犯的预测效能
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[Abstract]Objective：Toinvestigatethepredictiveeficiencyofsuper-resolutionreconstructionradiomicsforextraprostatic extension（EPE）of prostatecancer.Methods：Atotalof107patientswhounderwentradical prostatectomyforprostatecancer wereenrolled.AllpatientsunderwentMRIscansbeforesurgeryandthenrandomlydividedintoatrainingcohort（74cases） andatestingcohort（33cases）ataratioof7：3.Allimageswerereconstructedwithsuper-resolutionreconstruction.ROI were manually outlined onthe T 2 WI images before and after reconstruction，and radiomics features were extracted.Least absolute shrinkageandselectionoperator（LASSO）regresionwasused toreduce dimensionalityandconstructthemodel. ROCcurvesanddecisioncurves were drawn toevaluate theperformanceandclinicalnet benefitof themodel.DeLong testwasused tocompare theAUC，andtheMcNemar test wasused tocompare theaccuracyand specificity.Results： Postoperative pathology of 1O7 cases confirmed that 40 cases （37.38 % ）had EPE.7 radiomics features from image dataset beforereconstructionand6afterreconstructioncloselyrelatedtoEPEwereselected.Andlogisticregresion（LR）clssifier wasusedtoconstructradiomicsmodelsbeforeandafterreconstruction.TheAUCsof themodelbeforereconstructionin thetraining and testing cohorts were 0.819（95%CI 0.708-0.930）and 0.738（95%CI ），while those of the model after reconstruction were 0.852（95%CI 0.757-0.946 ）and 0.766（95%CI 0.547-0.985 ），respectively. There was no significant difference in AUC between the two radiomics models（ P =0.70），while there were significant difference inaccuracyand specificity（both P <0.05）.The decision curve analysis showed that the model after reconstruction had beter clinical net benefits.Conclusions：Super-resolutionreconstructiontechnologycanimprovethepredictiveperformanceforEPEofprostate cancer，which is helpful for clinical preoperative assessment and treatment decision-making.
[Keywords]Super-resolutionreconstruction;Radiomics;Prostatecancer;Extracapsularextension;Magneticresonanceiaging; Diagnosis
前列腺癌是男性泌尿生殖系统最常见的恶性肿瘤之一，准确诊断和分期对制订最佳治疗方案和改善预后至关重要[1]。（剩余7465字）
