CT多期增强扫描特征模型对KIT第11号外显子突变型胃肠道间质瘤的预测效能

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[Abstract]Objective：ToinvestigatethepredictiveefciencyofamodelbasedonmultiphaseenhancedCTfeaturesfor diagnosinggastrointestinalstromaltumor（GIST）withKIexon11mutation.Methods：Aretrospectivecolectionofmultiphase enhancedCTfeatureswasperformedin86GISTpatients，andtheywerecategorizedbasedonKITexon11mutationresults intothemutant GISTgroup（71cases）andthe non-mutant GISTgroup（15cases）.Diferencesin CTfeatures between the two groups were compared using t -test or χ2 test.Univariate analysis was performed to identify potential predictors of KIT exon11mutantGISTs，whichwerethenincorporatedintoapredictivemodel，andthepredictiveeficiencyofthemodel was evaluated using ROC curve analysis.Results ∴ The mutant GIST group generally showed moderate enhancement during thevenousphase，whilethenon-mutantGISTgroupmostlyshowedmarkedenhancement，withasignificantdiferencebetween the two groups （ P<0.05 ）. CT value，enhancement degree and rate in venous phase of the mutant GIST group were lower than those of the non-mutant GIST group （all P<0.05 ）.Univariate analysis revealed that the enhancement classification，degree，rate and CT value in venous phase were the risk factors for the mutant GIST（all P <0.05），and the combined model constructed withtheabovefourriskfactorshadanAUCofO.761forpredictingthemutantGIST.Conclusions：Theenhancement clasification，degre，rateandCTvalueinvenousphasearetheriskfactorsforKITexon11mutantGIST，andthemodel based on the above factors shows a good performance in identifying GIST with KIT exon 11 mutation.

[Keywords] Gastrointestinal stromal tumor;KIT gene;Tomography，X-ray computed

胃肠道间质瘤（gastrointestinal stromal tumor，GIST）是一种最常见的消化系统间叶源性肿瘤，其发生及对伊马替尼疗效均与原癌基因KIT和PDGFRA突变有关。（剩余6472字）