IVIM模型对直肠腺癌壁外血管侵犯的诊断价值及IVIM各参数值与Ki-67的相关性

打开文本图片集

[Abstract]Objective：Toexplorethediagnosticvalueoftheintravoxelincoherentmotion（IVIM）modelindetectingextra-mural vascularinvasion（EMVI）inrectaladenocarcinoma，andtoanalyzethecorrelations betweenIVIMparametersandKi-67 expresion.Methods：Atotalof36patientswithpathologicallconfirmedrectaladenocarcinomawereenrolledanddividedinto theEMVIpositivegroup（16cases）andEMVInegativegroup（2Ocases）．ThelesionIVIMparameters were measured，such as ADCstandard，ADCslow，ADCfast ，perfusion fraction （f），distribution diffusion coefficient（DDC），diffusion heterogeneity index（α）. Thedifferencesineach parameterbetweenthetwogroupswerecompared，ndtheparameterswithstatisticallysignificant diferenceswereincludedintheROCcurvetoevaluateeficacyinthediferentialdiagnosisofEMVInegativeandposie. Spearmancorrelationanalysis wasused to analyze the correlations between parametersand Ki-67level.Results ：ADCslow ， （20 ADCfast，f and DDC in the EMVI positive group were higher than those in the negative group（all P<0.05 ），whilethere were no significant differences in ADC standard or α between the two groups（both P>0.05 ）. For EMVI assessment， ADCfast had the highest AUC（O.918），and when the diagnostic threshold was 5.045×10-3mm2/s，ADCfast had the sensitivity and specificity of O.875and O.943，respectively. Spearman correlation analysis indicated that ADCstandard ， ADCslow ，f，DDC and α were all negatively correlated with Ki-67（all P<0.05 ）.Conclusions：The IVIM model has a high value in evaluating EMVI of rectal adenocarcinoma，and among all IVIM parameters， ADCfast demonstrates the highest diagnostic accuracy.

[Keywords]Rectalneoplasms;Adenocarcinoma;Itravoxelincoherentmotion;Ki-67;Extra-muralvascularinvasion;Magetic resonance imaging

结直肠癌是世界上第三大常见癌症，也是第二常见的癌症死亡原因[1]。（剩余7520字）