SWE与 BRAFV600E 基因检测对超声引导下FNAC 结果不确定甲状腺结节的诊断价值
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[Abstract] Objective： To investigate the diagnostic value of shear wave elastography （SWE）， BRAFV600E gene detection and theircombinationinthyroidnoduleswithuncertainresultsofultrasound-guidedfineneedleaspirationcytology（FNAC）. Methods：Atotalof132patientswith132uncertainthyroidndulesasthefirstFNACresultwereselectedasthestudy subjects.All patients underwent SWE，FNAC，and BRAFV600E detection，and 132 nodules were diagnosed as C-TIRADS category 3-5 nodules.Using postoperativepathologicalresultsasthegoldstandard，ROCcurveswereconstructedtoexplore the diagnostic value of SWE，BRAFV600E detection and the two combination for FNAC uncertain thyroid nodules.Results：Pathological confirmationaftersurgeryrevealed thatamong the132nodules，32werebenignnodulesand10O weremalignantnodules.E max （204 value had a statistically significant difference between benign and malignant nodules（ P <0.05），with the AUC of O.847 and the optimal cutoff value of 37.5 kPa. BRAFV600E mutation hadaproportion of 76.O%in malignant nodules，higher than thatin benign nodules 6.25%，P<0.05 ），with the AUC of 0.849.While the AUC of combined SWE and BRAFV600E was 0.855，higher than that of SWE alone（ P<0.05 ）.Conclusions：Compared with SWE alone，the combined use of BRAFV600E gene detection andSWEsignificantlyimprovesthediagnosticaccuracyforFNACuncertainthyroidnodules，ofersmorereliableinformationto support clinical decision-making.
[Key words] Shear wave elastography;Thyroid nodules;Fine needle aspiration cytology; BRAFV600E gene
我国甲状腺结节的检出率为 24.4%～61.9%[1] 其中甲状腺癌占 7%～15%[2] 。（剩余8709字）
