血清胱抑素C超敏C反应蛋白糖类抗原125与非ST段抬高型急性冠状动脉综合征病情严重程度相关研究

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【Abstract】 Objective To analyze the correlation between serum cystatin C（CysC），hypersensitive C-reactive protein （hs-CRP），carbohydrate antigen125（CA125）andthe severity of non-ST segment elevation acute coronary syndrome.MethodsA total of 92 patients with non-ST elevation acute coronary syndrome treated in Zhengzhou People's Hospital from January 2O23 to March 2O24 were classified into group A，81 healthy patients in the hospital during the same period were classified into group B，and group A was divided into non-ST elevation myocardial infarction group （22 cases）and unstable angina pectoris group （70 cases）.Serum CysC，hs-CRP，CA125 levels and global acute coronary event registry（GRACE）scores were compared among all groups，and patients in group A were divided into low-risk group （21 cases）， medium-risk group（48 cases）and high-risk group（23 cases）according to GRACE scores.The serum levels of CysC，hs-CRP and CA125 in 3 groups were compared，and the correlation between the serum levels of CysC，hs-CRP and CA125 and GRACE scores was analyzed.ResultsThe levels of serum CysC，hs-CRP，CA125 and GRACE scores in non-ST elevation myocardial infarction group and unstable angina pectoris group were higher than those in group B（ F =92.509，283.679，2346.068，440.602，P<0.001）. The levels of serum CysC，hs-CRPand CA125 in non-ST segment elevation acute coronary syndrome patients in low-risk group，medium-risk group and high-risk group were increased （ F =11.397，24.129，51.789， P <0.001）. Serum CysC，hs - CRPand CA125 levels were positively correlated with GRACE scores （r=0.486，0.476，0.482， P <0.05）. ConclusionThe serum concentrations of CysC，hs -CRP and CA125 in patients with non-ST elevation acute coronarysyndromeareatahigh level，and theconcentrationsof these markers will graduallyincrease with the aggravationofpatients‘disease.Thechanges inthelevelsof theaboveserological indicatorsare positivelycorrelated withthe severityofnon-STelevation acutecoronarysyndrome，itcanreflecttheseverityof thepatient'scondition and inflammatory response.

【Key words】 Serum cystatin C；C-reactive proteins;Carbohydrate antigen 125;Acute coronary syndrome;CorrelationDOI：10.19522/j.cnki.1671-5098.2025.07.009

非ST段抬高型急性冠状动脉综合征是一种常见且严重的心血管疾病，其涉及心脏血流的暂时或持久减少，通常由冠状动脉内的血栓形成引起。（剩余6680字）