拉曼光谱技术在口腔鳞状细胞癌和口腔潜在恶性疾病诊断和治疗中的应用进展

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[大键词」拉曼光谱；病埋诊断；口腔状细胞癌；口腔潜在恶性疾病；人工智能

[中图分类号]R739.8 [文献标志码]A [doi] 10.7518/gjkq.2026111

Advancements intheapplicationofRamanspectroscopyfor the diagnosisand treatment oforalsquamous cellcarcinomaand oral potentiallymalignant disorders

ZhangLinhan，TangYaling

StateKeyLaboratoryofOralDiseases&NationalCenterforStomatology&NationalClinicalResearchCenterforOral Diseases&eptralthologyWestnaHospialotomatologyicuanUversityngduin Supportedby：ClinicalResearchProjectFundedbyWestChinaHospitalofStomatologyichuanUniversity-M 202308）

Correspondence：TangYaling，Email：tangyaling@scu.edu.cn

[Abstract]Raman spectroscopy（RS） provides characteristic spectral information that represents specific molecular “fingerprints”ofsubstances.This techniqueenables theidentificationofsubtlebiochemicalalterations in biological tissues，offeringadvantagessuchasrapidnalysis，eal-timecapabilitynoninvasivenes，andminimalsamplepreparationrequirements.Itdemonstrates considerable promise in thediagnosisand managementoforal squamous cellcarcinoma （OSCC）and oral potentially malignant disorders （OPMDs）.This review summarizes recent advancements in RS-based diagnosis of OSCCand OPMDs using tissue and biofluid samples.The applications ofRS in assessing surgical margins duringOSCCresection，investigatingrelevantmolecularmechanisms，andenablingartificial intellgence-assisteddiagnosis are briefly outlined.

[Key words]Raman spectroscopy；pathological diagnosis；oral squamouscellcarcinoma；oral potentially malignant disorders;artificial intelligence

口腔鳞状细胞癌（oral squamouscell carcino-ma，OSCC）约占口腔恶性肿瘤的 80%～90% ，2020年全球共有37.7万例新发病例。（剩余20698字）