变异链球菌次级代谢产物Mutanobactin的研究进展

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[中图分类号]R78[文献标志码]A[doi] 10.7518/gjkq.2026204

[Abstract]Dentalcaries isa chronic infectious disease occurring inthehard tissueofteethunderthe influenceof bacteria.Streptococus mutans（S.mutans）isconsideredthemajor etiologicalagentofdentalcaries in humans.Mutanobactin is oneof thesecondary metabolitesofS.mutans.Itisoneof non-ribosomal peptide/polyketide hybrid products and is mainlysynthesizedbythemubgenelocated intheTnSmu2 gene island.Additionally，themajor typesofthis productare MutanobactinA，B，C，andD，whichcanbesynthesized invitro.TheMutanobactinofS.mutansplaysanimportantrole inphysiological functions ranging from oxidative stressresistanceand interspeciescompetitionto immunoregulation. Moreover，itsproductionisectedbyariousregulatorymechanismsinvivo，theexteralenvironment，ndcommesal bacteria.Thiswork mainlyreviews thesynthesis，physiologicalrole，andrelatedregulatorymechanismsofMutanobactin to provide anew horizon for elucidating the caries virulenceofS.mutans and new methods fororal microecologicalregulation and management of caries.

[Keywords]Streptococcus mutans；secondary metabolite；Mutanobactin；dental caries；microecological balance

龋病是在以细菌为主的多因素作用下，发生于牙体硬组织的慢性感染性疾病，是全世界最普遍的非传染性疾病之一。（剩余16890字）