铜死亡在牙周炎中的研究进展

[中图分类号] R781.4 [文献标志码]A [doi] 10.7518/gjkq.2026107

Researchprogressoncuproptosis inperiodontitis

CenterofStomatology，TongjiHospital，TongjiMedicalCollege，HuazhongUniversityofSienceandTechnology& SchoolofStomatologyTongjiMedicalColege，HuazhongUniversityofcienceandechnology&HubeiProvnceKey LaboratoryofOralandMaxillofacialDevelopmentandRegeneration，Wuhan43oo3o，China

Supportedby：National Natural ScienceFoundationofChina （8180o98l）;Natural ScienceFoundationofHubeiProvinceofChina （2023AFB653，2023AFB765）

Correspondence： Zhu Guangxun， Email： zhuguangxun@163.com

[Abstract]Periodontitis isanimmune-inflammatoryresponse triggeredbyperiodontalpathogens.Inthiscondition，disruptedimmune responses and chronic inflammation play crucial roles in the degradationof periodontal issues.Cuproptosis，arecentlyidentifiedforofprogammedcelldath，istriggeredbyexcessiveintracellularcoperionsandspecificallytargets thetricarboxylicacidcycle.Itischaracterized bytheabnormaloligomerizationof mitochondrial lipoacylated proteins and the loss ofiron-sulfur cluster proteins.Cuproptosis has garnered significantatention for its nonnegligible role inthedevelopmentand progression of variousdiseases，including cardiovascular diseases，neurodegenerativedisorders，and cancers.Cuproptosis-related genes participate inthepathogenesis of periodontitis bymodulating immune cells and cytokines.The abnormal expresionofthese genes reflects the disease status andaids in clinicaldiagnosis，providing noveltherapeutic targets for periodontitis treatment.Considering these insights，this work presents a comprehensivereviewof the molecular mechanisms underlying cuproptosis and itsrole in the initiationand progression of periodontitis.

[Key words] cuproptosis; periodontitis; cuproptosis-related genes

铜死亡是由Tsvetkov等[于2022年提出的一种由细胞内铜积累引发的程序性细胞死亡的独特形式。（剩余14312字）