程序性细胞死亡配体1与头颈癌风险的孟德尔随机化研究

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[中图分类号]R739.8[文献标志码]A[doi] 10.7518/gjkq.2026208

AMendelianrandomizationstudyof programmedcelldeathligand1withtheriskofheadandneckcancer

ShangHongyue，LiuTejun，Yaoanman，LuYueting，ongBo，ongWeiing，ZhangJi'o Supportedby： Central Government Guides Local ScienceAnd Technology DevelopmentFund Projects （246Z7762G） Correspondence： Liu Tiejun， Email： 47300561@hebmu.edu.cn

[Abstract]ObjectiveThis study aimed to assessthe causal relationship between programmed celldeath ligand 1 （PDL1）and the riskof head and neckcancer.MethodsMendelianrandomization （MR）was performedusing large-scale geneticdatatoevaluatethecausalrelationshipbetweenPD-L1andtheriskofdiferent typesofheadandneckcancers via inverse variance weighted （IVW），Mendelian randomization-Egger （MR-Egger），simple mode，and weighted median. Additionaly， MR-Egger and Mendelian randomization pleiotropy resiual sum andoutlier （MR-PRESSO） were used to analyze horizontal pleiotropy，Cochran’sQtest was performed toexamine heterogeneityand leave-one-out experimentwas conducted to measure sensitivity.ResultsThe genetic prediction results revealeda causal relationship between PD-L1 and head and neck squamous cell carcinoma （HNSCC） （OH R=1.000 3 ， 95%Cl ：1.000 0-1.000 6， P=0.049 ）andbetween PD-L1 and oral cavity and oropharyngeal cancer （OC&PC） （OF ：=1.000 3 95% CI： 1.000 1-1.000 6， P=0.018 ）. Conclusion PD-L1 may be a risk factor for the development of HNSCC and OC&PC.

[Keywords]Mendelian randomization;programmedcelldeath ligand1；head and neck cancer；risk

头颈部恶性肿瘤是全球七大常见恶性肿瘤之一，起源于喉、咽和口腔的黏膜组织，其主要亚类包括口腔鳞状细胞癌、口咽鳞状细胞癌和喉鳞状细胞癌等。（剩余16642字）