pH响应性海藻酸钠/丝素蛋白复合水凝胶的制备及其释药性能

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关键词氧化海藻酸钠；多巴胺；丝素蛋白；水凝胶；释药性能； pH 响应

中图分类号：TB332 文献标志码：A

DOI：10.13338/j.issn.1006-8341.2025.05.003

Preparation and drug release performance study of pH-responsive sodium alginate/silk fibroin composite hydrogel

LIN Haitao，CHAO Mengying，XU Liang，LING Xinlong （School of Biological and Chemical Engineering，Guangxi University of Science andTechnology，Liuzhou545oo6，Guangxi，China）

AbstractIn order to prepare natural polymer hydrogels with pH-responsive drug release properties，sodium alginate was oxidized with ammonium persulfate（APS） to obtain oxidized sodium alginate（OSA）.OSA was then grafted with dopamine （DA） through an amidation reaction to prepare dopamine-grafted oxidized sodium alginate（OSA-DA）. OSA-DA was cross-linked with silk fibroin（SF）and Fe3+ was introduced to prepare a composite hydrogel with a double-network structure. The structure，water absorption performance，drug release performance，antioxidant properties and adhesion properties of the hydrogel were characterized and tested.The results show that the optimal preparation conditions for the hydrogel were nSA：nAPS=1：8 and reaction for of 1：2 to prepare OSA-DA，and mOSA-DA mSF=1：1 .With the increase of silk fibroin content，the swelling rate of the hydrogel first increased and then decreased.When mOSA-DA：mSF is 1：1 ，the swelling rate of the hydrogel reached the maximum，which is 638.1% ： The sweling rate and drug release performance of the hydrogel were significantly affected by the environmental pH .Inanacidic environment，it rapidly swelled and decomposed，with a fast drug release rate.In an alkaline environment，it swelled stably with a slow drug release rate.It also exhibits excellent antioxidant properties and good adhesion.

Keywordsoxidized sodium alginate；dopamine； silk fibroin；hydrogel； drug release property;pH response

0 引言

水凝胶作为高分子凝胶1的一种，以水为溶胀介质，拥有稳定的三维结构，是一种具有大量亲水基团的功能型高分子材料[2-3]，具备良好溶胀性、高含水量以及调控性，可通过物理和化学方法改变网络结构性质[4-5]，在药物释放载体、伤口敷料、组织工程等医疗领域应用广泛[6-7]

海藻酸钠（SA）是一种天然的高分子多糖碳水化合物，其结构中含有大量的羧基和羟基[8]，具有良好的亲水性、生物相容性、低毒性和可再生性，是制备水凝胶的良好选择。（剩余15481字）