负载姜黄素的醋酸纤维素纳米纤维复合水凝胶的性能及其抗氧化分析

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关键词姜黄素；季铵化壳聚糖；醋酸纤维素；复合水凝胶；流变；抗氧化 中图分类号：TS102.52；R318.08 文献标志码：A DOI：10.13338/j.issn.1006-8341.2025.05.001

Performance and antioxidant analysis of curcumin-loaded cellulose acetate nanofiber composite hydrogels

QI Yiming1，WANG Shixin1，DENG Hongbing 1，2

（1.College of Textiles，Donghua University，Shanghai 20l62o，China; 2.Innovation Center for Textile Science and Technology，Donghua University，Shanghai 2O1620，China）

AbstractTo construct a novel hydrogel dressing with both excellent mechanical properties and free radical scavenging capability，a nanofiber-reinforced composite hydrogel （QCS/OD/CA-Cur）

was prepared using quaternized chitosan（QCS）and oxidized dextran（OD）as the hydrogel matrix，incorporating curcumin-loaded cellulose acetate nanofibers （CA-Cur）.The experimental results demonstrate that the introduction of nanofibers significantly enhanced the mechanical properties of the hydrogels.The compressive strength and tensile strength of the nanocomposite hydrogels were1.8 times and 2.4 times higher than those of the hydrogel without fibers，respectively.Furthermore，significant improvements were observed in sweling behavior，strain capacity，and stability.Free radical scavenging assays revealed that the QCS/OD/CA-Cur hydrogel exhibited outstanding antioxidant performance，achieving a scavenging rate of 60.35% against ABTS cation radicals.The materials used in this hydrogel are natural polymers and their derivatives，which possess good biocompatibility，providing experimental evidence and application potential for the development of biologically friendly antioxidant medical dressings.

Keywordscurcumin；quaternized chitosan；cellulose acetate；composite hydrogel；rheology；antioxidant

0 引言

随着人们对伤口愈合机制的不断探索和医疗水平的进步，只具有简单覆盖保护作用的伤口敷料已经不能满足患者对敷料日益增长的功能要求。（剩余13000字）