2016一2024年人源类器官伦理国际研究的可视化分析

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[中图分类号]R-052 [文献标志码]A [文章编号]1001-8565（2025）11-1398-11

DOI：10.12026/j. issn.1001-8565.2025.11.04

Abstract： With the rapid advancement of science and technology，human organoid technology has demonstrated immense potential in medical research and treatment，but ithas also raised complex ethical issues. Ethical research on human organoid has gradually becomea hot field ofconcerm in the international academic community.Taking 262 papers from the Web of Science core database from 2Ol6 to 2O24 as a sample，this paperemployed bibliometrics and visualization methods to analyze the hotspots and evolutionary trends of international research on the ethics of human organoid.The results showed that international research on the ethics of human organoid exhibited a significant growth trend，going through three phases： a slow accumulation period，a sustained explosion period，and a circuitous growth period.The primary research forces were concentrated in the United States，China，the United Kingdom，and Italy，with China gradually emerging in this domain.The research hotspots were mainly focused on the following aspects.The first was the research of clasical ethical isses，encompassing an overviewof the overall ethicalisues in the researchand application of human organoid technology，and the ethical issues of organoid biobanks.The second was the new challenges in ethical issues，including the moral status and ethical governance of brain organoids，embryoid bodies，and gonadal organoids.The third was ethical issues arising from cros-disciplinary applications，covering the ethical challenges posed by chimeras formed through transplanting human brain organoid into non-human animals and hybridscreated by connecting human brain organoid with artificial intelligence（AI），robots，and other nonbiologicalentities.As technology continues toadvance，the complexity and importance of ethical issues related tohuman organoid willpersistently increase，and research in this field willcontinue to deepen and expand in the future.

Keywords： ethics of human organoid; science and technology ethics；moral status； ethical governance

0 引言

随着生物医学技术的发展，人源类器官的研究正逐渐成为生命科学与医学领域的前沿话题。（剩余15024字）