氧气反应-电感耦合等离子体串联质谱法 (ICP-MS/MS）测定钛及钛合金中痕量铜

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中图分类号：TB9 文献标志码：A文章编号：1674-5124（2025）08-0080-07

Abstract： The accurate determination of trace copper elements in titanium and its alloys is of great significance for evaluating material performance and quality control. However， existing quantitative methods exhibit notable shortcomings in detecting trace copper. Traditional inductively coupled plasma mass spectrometry （ICPMS）faces severe mass spectral interference when measuring copper in titanium matrices. Polyatomic ions of titanium oxides and hydroxides （such as [TiO+] and [TiOH]） overlap with the mass numbers of copper's primary isotopes （ -63Cu and 65Cu ，leading to elevated background signals and poorer detection limits. Therefore， there is an urgent need to develop a new method capable of efectively eliminating interference and improving detection sensitivity. This study employs inductively coupled plasma tandem mass spectrometry （ICP-MS/MS） combined with oxygen reaction mode， significantly reducing interference from the titanium matrix in copper determination.The established method demonstrates excelent analytical performance，with a linear correlation coeficient of the calibration curve reaching 0.99 and the detection limit of sample as low as 1.8ng/g .Seven repeated measurements of four high-purity titanium and titanium alloy standard reference materials showed that the determined values of 63Cu all fell within the certified ranges， with absolute relative errors <7.7% and relative standard deviations （RSD） <2.5% .Theoxygenreaction mode-ICP-MS/MSmethod developed in this study effectively resolves interference issues in trace copper determination within titanium matrices，offering high sensitivity，highaccuracy，and excellent repeatability.Itcanprovide areliable analytical approach for quality control of titanium and titanium alloy products.

Keywords： oxygen reaction; inductively coupled plasma tandem mass spectrometry（ICP-MS/MS）; titanium and titanium alloys; trace copper

0 引言

钛及钛合金具有高比强度、优异的生物相容性、耐腐蚀和耐高温性能，在金属材料中被称为“全能金属"[1]。（剩余13667字）