沙库巴曲缬沙坦联合血液透析对慢性肾脏病患者炎症状态及骨代谢的影响

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中图分类号：R692 文献标识码：A文章编号：1006-1959（2025）14-0119-04

DOI：10.3969/j.issn.1006-1959.2025.14.023

Abstract：ObjectieTivestgateheectofsacubitrlalsartanombindwitemodialysisoniflammatorateandonemeabolismin patientswithchonickidneydiseaseMethodsAtotalof6patientsithchoickidneydiseasediagosedndtreatedinShangraoGuangin DistrictPeoplesspitalfoJuarytoOctoereeseleedsteseachjectsodngtoeadumbeableethod theyweredividedintoooloddoith3Oatitsiachopotroastreatedimodalisd groupwastraedwicbitillsaraosisoftolouprapetevelfatorctorseacti protein（RP），atiUabloda phosphatase（BALP）werecomparedbetweenthetwogroups.ResultsThetotalefectiverateoftreatmentinthestudygroup 96.67% ）washigher than that in the control group （73.33 % ）（ P< 0.05）.Compared with thecontrol group，thelevelsofCRP，Scr，BUN，BALPand serumphosphorus inthe study group were lower after treatment，while the level of serum calcium was higher（ P <0.05）.Conclusion Sacubitril valsartan combined with hemodialysissfiteetinpatitsiocdeydseaseichpoethifaatoyatedeetabolcactoee of patients，and improve their renal function of patients.It is worthy of clinical application.

Key Words：Sacubactril valsartan; Hemodialysis; Chronic kidney disease;Inflammatory state; Bone metabolism

慢性肾脏疾病（chronic kidneydisease）是一种长期存在的状况，源自各种原始病症，特征是肾功能持续退化超过3个月可伴随着一系列临床表现和代谢紊乱。（剩余5379字）