CSF2作为肺鳞状细胞癌预后因子及相关肿瘤微环境指标的可能性研究

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中图分类号：R734.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2025.14.001

文章编号：1006-1959（2025）14-0001-12

Abstract：OjetiTofndthicatoselatedtorogresiondpgosisofUCdtoepeolotulaicto （CSF2）isaproosticfactorandtoricroenviontindexofLUSCMetodsThegeneexpresionprofiledatarelatedtoLUSCnCGA databasewereodroporfselpotsllfaticellU calculatedbyestimatiometodandCiberSortmetodGeneseteichentaalysis（SEA）aspefodoCSF2toevaluateteproportioof TCs，andsoatalssfodtofuteeeelatoseCFndelaedcalusfUCialsn vivoexpermentsthexpresfFaokedutnelloutingit8CK8）eveseorealyisodealingd formationwereusedtoproetheproiferationmigrationndinvasionofLUSCcel.ResultsTheexpressonofCSF2intmoisssas significantlyaaiasdeileU KEGnalysisodatFstetalafootas）o ledtosignfcanteeeicellpolferaoigatodaso（O）.CocsioFaotetialaptic prognostic indicator for TME in LUSC patients.

KeyWords：Lungsquamouscellcarcinoma;Tumormicroenvironment;Colonystimulatingfactor2;Clinicalpathologyandprogosis

肺鳞状细胞癌（LUSC）占所有非小细胞肺癌（NSCLC）的 30%[1] ，在老年男性中更为普遍，并与吸烟密切相关。（剩余17124字）