六味糖克汤干预糖尿病肾病大鼠炎症因子的研究

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中图分类号：R587.2；R692 文献标识码：A DOI：10.3969/j.issn.1006-1959.2025.14.011

文章编号：1006-1959（2025）14-0067-04

Abstract：ObectiveTvestgatethtsofLueangeeoctioolodcoseifaatoactodalfuctioatsi diabeticnepropathyethosFortyeanatsedolyividedintoopscudingatsinoalopdthaats werefed with high-fatsugardiet for4weeksand thenfasted for 12h .The diabetic kidney disease （DKD） rat model was established by streptozotocin （STZ）.The rats were divided into DKD model group，DKD + AICAR group，DKD +low -concentration Chinese medicine group，and |DKD+high- concentrationCinesemedicinegoup.TheoalgroupndteDKDmodelgouperegivenitrapeioealijectioofoalsalinetheKD + （20号 AICARgroupwasgivenintraperitonealinjectionofadenosine-phosphate-activatedkinase（AMPK）activatorAICAR3Omg/kg，the DKD+low- concentrationChineseedicingroupasivenlowoncentrationChineseedicinendteD+igoncetrtionCineseedicinegoua givenhighoraieedatscdelsiod）etid urea nitrogen （BUN） were analyzed by automatic analyzer.The expresson of inflammatory factors TNF- ∇⋅α∝ and IL-6 was detected.Results Compared with the DKD model group，the FBG level inthe DKD+high-concentration Chinese medicine group was decreased（ P<0.01 ），but compared with the DKD + AICARgroup，therewasno significant difference（ P>0 0.05）.Compared with theDKD model group，the Scrand BUNof theChinesemedicine group and the DKD + AICAR group were significantly decreased（ P<0.01 ），but there was no significant difference between DKD+high concentration Chinese medicine group and DKD + AICARgroup P> 0.05）.Compared with theDKD model group，thelevelsof TNF- αα∝α and IL-6 in the kidney tissues of the Chinese medicine group and the DKD + AICAR group were significantly down-regulated（P 0.05）.ConclusionLiuweiTangkedcoctioncanimprovethelevelsofblodgucosenalfunctionandinflammatoryactorsinDats. Kevwords：Diabetic nephroDathv： Inflammatorv factors：Liuwei Tangke decoction

据国际糖尿病联盟估计，2045年糖尿病患者人数将增至6.3亿。（剩余6639字）