miRNAS在卵巢癌发病机制和治疗耐药中的作用

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Roleof miRNAsin the Pathogenesis and TreatmentResistance of Ovarian Cancer

WANGFang12，YANGYongxiu12.3

（1.TheFirstSchool ofClinical Medicine，Lanzhou University，Lanzhou 73OoOo，Gansu，China；

partmentofObstetricsandGynecology，theFirstHospitalofLanzhou UniversityLanzhou 73ooo，Gansu，China：

3.Gansu Province Gynecological Tumor Clinical Research Center，Lanzhou 73oooo，Gansu，China）

Abstract：Ovariancancer（OC）isthemaincauseofeathingyecologicalcancer.OCissyptomaticinthearlystageandhasnspecific symptoms in the late stage.Therefore，more than 7 5 % of OC cases are diagnosed as advanced stage.It has been reported that a variety of epigenetic fctorsch ofultipleol alsoffecteyelatedecnismathwauchsJAKSis，igaingPKigalingthay3/ATalingta InaditiontoogestsoseofOCtoandlocalofoelld thispaperintends toclarifytherelationshipbetweenmiRNAsandOC，focusingontheefectofmiRNAsonOCsignalingpathway.

Keywords：Drug resistance；Ovarian cancer；Pathogenesis；MicroRNA

卵巢癌是全球第三大最常见的妇科恶性肿瘤肿瘤由多种组织病理学实体组成，卵巢癌的最常见的组织学类型包括：浆液性卵巢癌、子宫内膜样卵巢癌、粘液性卵巢癌、透明细胞卵巢癌。（剩余14516字）